The Collaborative Center for X-Linked Dystonia-Parkinsonism (CCXDP) is a global disease consortium based at Massachusetts General Hospital that is focused exclusively on a rare neurodegenerative disorder endemic to the Philippines. We are an international coalition of scientists, physicians, and industry partners throughout North America, Europe, and Asia all working together to solve X-Linked Dystonia-Parkinsonism (XDP), a severe movement disorder. The hub of our network is a group of core investigators at MGH with affiliations spanning Harvard Medical School, the Harvard Stem Cell Institute, and the Broad Institute.

CCXDP is seeking a Research Scientist to lead a broad range of studies applying genome editing technologies to interrogate DNA sequence variants linked to XDP and related movement disorders in induced pluripotent stem cell (iPSC) models. We are looking for individuals who share our passion for solving rare disorders of the brain and who enjoy working in multi-disciplinary teams in a fast-paced research environment.  You will work closely with a dynamic team that includes senior investigators, junior faculty members, PhD-level staff scientists, research technicians, and students, while contributing to collaborative projects involving CCXDP-supported laboratories around the world.

What you’ll do:

• Perform studies of induced pluripotent stem cells using CRISPR-based genome editing methods to alter disease-related DNA sequence variants of interest.
• Differentiate engineered iPSC lines towards neuronal and glial lineages using established protocols.
• Characterize cellular phenotypes in engineered iPSCs using a range of molecular, biochemical, and/or imaging-based assays.
• Investigate, create, and develop new methods and technologies for research advancements.
• Prepare written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
• Contribute to research presentations at local, national, and international meetings.
• Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

What we're looking for:

• Msc (required) or PhD (preferred) in relevant biomedical discipline with 3-5 years of experience in a related research field.
• Experience with mammalian tissue culture with an emphasis on iPSCs
• Experience with CRISPR-based genome editing methods and related molecular genetic techniques.
• Ability to work independently and as a team member.
• Excellent organizational and communication skills
• Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
• Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.