Are you a translational physician/scientist, with experience in genetics and early clinical research? Do you share a desire to elucidate the genetic basis of diseases, advance biological scientific knowledge and drive the discovery and development of new therapeutics? If so, read more about this unique new role.
GSK’s ambition is to become the industry leader in genetically validated targets. A dedicated organization, Human Genetics (HG), has been created to achieve this, harnessing recent scientific advancements with a focus on human-derived data and leveraging external partnerships to translate genetic information to high quality targets, ultimately contributing to better medicines with reduced attrition.
In this role, you will work collaboratively with scientists in Human Genetics and multiple Research Units to design experiments and clinical studies (recall by genotype studies) which elucidate the function of genetics and shed light on biology contributing to the identification of novel drug targets. You will nurture relationships within the industry and academic community, to develop centers who can complete studies based on genetic information to address drug discovery and development questions.
The combination of your in-depth research experience in genetic and genomic science and your clinical training will lead to the development of ethical and efficient studies in humans which will drive the understanding of the impact of genetic variants in vivo. You will also bring breadth and depth of technical and leadership expertise, to successfully support projects through all phases of drug discovery and development.
The position is based at our R&D hubs in either Collegeville, PA (US) or Stevenage (UK). We welcome all qualified applicants and would be open to consider alternative flexible/remote arrangements, with a commitment to participate in team’s activities and/or travel as needed to perform successfully in the role.
This Director level role will provide YOU the opportunity to drive key activities to progress in your career at GSK. These responsibilities include some of the following:
Identify and implement opportunities for genetics-based science to improve GSK target quality and use human genetic evidence to drive decisions on target selection, validation and patient stratification.
Collaborate with internal teams to develop experiments and study proposals that will elucidate the role of genetic variants in patients of interest that can be efficiently operationalized in specialized settings in the US and Europe.
Drive the development and execution of collaborations, consortiums and other external relationships focused on the study of the effects of variants in humans.
Identify opportunities to leverage genetics of rare diseases to identify drug targets or address drug development questions.
Participate and lead project teams with GSK scientists and external collaborators.
Be responsible for effective communication of genetic findings, with expert interpretation, to relevant stakeholders and project teams.
Find creative solutions and work with agility to address challenging scientific questions.
Contribute to the developing science of drug target identification and validation, providing scientific expertise within Human Genetics and across the Research organization
Multiple Locations: see job posting text
We are looking for professionals with these required skills to achieve our goals:
MD and/or PhD with clinical research experience
Extensive knowledge of (human) genetics and translation into biological function, and ability to apply their experience to drug discovery and development.
Broad clinical knowledge and use of clinical research to explore biological questions
A track record of designing clinical studies to elucidate biological knowledge.
Experience in managing complex scientific activities, anticipating challenges in managing patient recruitment, and ability to anticipate and address compliance and governance requirements.
Experience in directing external scientific activities.
In addition to the above, the following characteristics would be an advantage:
Knowledge and experience in the use of observational data for research
Translation of rare disease context to common diseases
Being a subject matter expert in human genetics and applying genetics to drug discovery
Bringing strong leadership skills demonstrating vision and strategy and effective leadership of change.
Superior communication skills to have honest, truth seeking conversations, rather than being progression seeking.
GSK aims to improve the number of successful late stage clinical trials for innovative medicines, by both identifying and advancing drug targets that have strong evidence of a causal role in disease biology. The Human Genetics team leverages major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms, breakthrough understanding of biological pathways, functional genomics capabilities built upon rapid progress in gene editing, and leading industry-academia partnerships, in order to identify the best targets and to continue evaluation of targets through their life in the pipeline.
We are seeking motivated, innovative, skilled and experienced Individuals to join our expanding team within the Human Genetics department. Candidates should be keen to drive and apply state of the art analysis methods to inform decision making across the GSK pipeline, integrating diverse and complex data types to translate genetic signals into innovative new medicines for patients with unmet medical need.